Causes of Azoospermia: Genetic and Non-Genetic Factors

Reviewed by Dr. Sourabh Welling, Founder

Homeopathic infertility treatment at Welling Homeopathy, Mumbai

Azoospermia is a condition in which there are no sperm in the ejaculate. It is found in about 1 in 100 men and in a larger share of men with infertility. It can have genetic or non-genetic causes, and it is important to know which of the two main types a man has. This page explains the types, the causes, how azoospermia is diagnosed, the treatment options and Welling Homeopathy’s approach.

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Azoospermia at a glance

  • What it is: no sperm at all in the semen, found on semen analysis.
  • Two types: obstructive (sperm are made but blocked) and non-obstructive (the testicles make few or no sperm).
  • Genetic causes: Klinefelter syndrome (XXY), Y chromosome microdeletions and cystic fibrosis gene changes.
  • Key tests: repeat semen analysis, FSH, LH and testosterone, scrotal ultrasound, and genetic tests.
  • Our approach: tailor-made homeopathic treatment aimed at growing sperm count for natural conception.

What is azoospermia?

Azoospermia is a condition in which there are no sperm present in the ejaculate. It can be caused by genetic or non-genetic factors, and there are several different types that affect men differently.

In obstructive azoospermia the testicles make sperm normally, but a blockage in the tubes (the epididymis or vas deferens) stops it from reaching the semen. In non-obstructive azoospermia the testicles themselves make very few sperm or none. The difference decides the treatment, so it is the first thing a doctor works out.

Genetic causes of azoospermia

  • Klinefelter syndrome (XXY): an extra X chromosome causes abnormal testicular development and low testosterone
  • Y chromosome microdeletions: missing pieces of the Y chromosome (the AZF regions) that control sperm production
  • Cystic fibrosis gene (CFTR) changes: the vas deferens may be absent from birth (congenital bilateral absence of the vas deferens), causing obstructive azoospermia
  • Other chromosomal abnormalities and conditions such as Kallmann syndrome, in which hormone signals from the brain are missing

Non-genetic causes of azoospermia

  • Testicular injury or torsion, including damage during surgery on the groin or scrotum
  • Infections: mumps orchitis after puberty, epididymitis and sexually transmitted infections can damage the testicles or block the tubes
  • Undescended testicles that were not corrected in childhood
  • Varicocele, enlarged veins around the testicle
  • Chemotherapy and radiation, which can damage sperm-producing cells
  • Hormonal problems: low FSH and LH from the pituitary, or anabolic steroid and testosterone use, which switch off natural sperm production
  • Vasectomy or past surgery that blocked the vas deferens
  • Some medicines and heavy use of alcohol or marijuana

Environmental and lifestyle causes

Heat can damage sperm production. It can come from hot tubs, saunas, tight clothing, laptops used on the lap or working in a hot environment for long periods. Exposure to toxic chemicals such as pesticides, herbicides and solvents, found in some cleaning products, paints and varnishes, can also affect sperm quality.

A poor diet, obesity, smoking and heavy alcohol affect hormone levels that control male reproductive function. These factors more often lower the sperm count than cause a complete absence, but they are worth correcting.

How is azoospermia diagnosed?

The assessment usually includes:

  • Semen analysis, repeated at least twice, with the sample spun in a centrifuge to look for rare sperm
  • Physical examination of the testicles, vas deferens and any varicocele
  • Blood tests: FSH, LH and testosterone (FSH is usually high in non-obstructive and normal in obstructive azoospermia)
  • Scrotal ultrasound, and sometimes a transrectal ultrasound, to look for blockage
  • Genetic tests: karyotype, Y microdeletion test and CFTR testing where indicated
  • A man with azoospermia should also be tested for conditions such as varicocele and hypogonadism

Please see a doctor promptly for sudden severe scrotal pain or swelling, a hard testicular lump, or fever with a hot swollen testicle.

Treatment options for azoospermia

Treatment depends on the cause. For obstruction, surgery to repair the blockage can restore sperm in the semen. When the testicles make sperm but it cannot reach the semen, sperm can be collected directly by procedures such as PESA, TESA or micro-TESE and used with IVF and ICSI. In men with low FSH and LH, hormone therapy may restart sperm production.

Where the cause is genetic, such as Klinefelter syndrome or cystic fibrosis gene changes, assisted reproduction is often the route, and genetic counseling is advised. Surgery and hormone treatment can have side effects, so ask your doctor about them.

Our clinical experience with azoospermia

Our tailor made Homeopathy treatment for Azoospermia is very effective in growing sperm count fast and helping you conceive a child naturally.

To date, our global clinic has served patients from a staggering 108 countries, making a mark on the world map.

Our comprehensive approach ensures that sperm count doesn’t revert to zero after successful treatment, marking a new beginning for you and your family.

See our page on homeopathy treatment of azoospermia. Please continue any treatment your doctor has advised unless they tell you otherwise.

Dr. Sourabh Welling and the Welling Homeopathy team have over 25 years of experience treating patients, in our Mumbai clinics and online.

Consult a Welling specialist about azoospermia

Do not delay: share your reports and your history of treatment so far, and our specialists will plan your personal homeopathic treatment, in person at our Mumbai clinics or online from anywhere.

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Preventing azoospermia and living with it

Not all causes can be prevented, but you can lower the risk by avoiding exposure to toxic chemicals, protecting the testicles from injury, treating infections early, keeping a healthy weight, eating a diet rich in fruit and vegetables, avoiding anabolic steroids, and having regular check-ups.

A diagnosis of azoospermia can be hard. Seek support from your partner, family and friends, and talk with your doctor about how it affects your plans for a family.

Frequently asked questions about azoospermia

1. What is azoospermia?

Azoospermia means there are no sperm at all in the ejaculate. It is found on semen analysis and may be obstructive or non-obstructive.

2. What causes azoospermia?

Genetic causes (Klinefelter syndrome, Y microdeletions, cystic fibrosis gene changes) and non-genetic causes such as infection, injury, undescended testicles, varicocele, chemotherapy, hormonal problems and blocked tubes.

3. What is the difference between obstructive and non-obstructive azoospermia?

In obstructive azoospermia sperm are made but blocked; in non-obstructive azoospermia the testicles make few or none.

4. How is azoospermia diagnosed?

With at least two semen analyses, hormone tests (FSH, LH, testosterone), a scrotal ultrasound and, where indicated, genetic tests.

5. Can azoospermia be treated?

Often yes, depending on the cause: surgery for blockage, hormone therapy, sperm retrieval with ICSI, and individualised care such as homeopathy.

6. Can azoospermia be temporary?

Yes, in some men, for example after an infection, a medicine, steroid use or a hormonal problem that is corrected.

7. Can I father a child with azoospermia?

Some men can, using sperm retrieval and ICSI or after treatment of the cause. A detailed assessment shows which options are open.

8. Can I consult Welling Homeopathy online about azoospermia?

Yes. You can share your semen analyses and reports and consult our specialists online from anywhere. We have been consulting patients online for 25 years.

More on azoospermia and male infertility

To consult Welling Homeopathy experts, call +91 80 80 850 950.

Disclaimer: this page is for information only and is not a substitute for professional medical advice, diagnosis or treatment. Results vary from person to person.

Dr. Sourabh Welling, founder of Welling Homeopathy

Reviewed by

Dr. Sourabh Welling — Founder

Dr. Sourabh Welling is a practicing homeopathy doctor and founder of Welling Homeopathy, Mumbai, with 25 years of clinical experience. A multiple award winner at national and international levels, he focuses on individualized homeopathic care for chronic and complex health conditions. He leads a team of experienced doctors providing personalized consultations based on each patient’s symptoms, health history and individual circumstances.

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